Process for producing monoclonal antibodies against human T cell

Details Process for producing monoclonal antibodies against human T cell Process for producing monoclonal antibodies against human T cell

1994-07-21

1997-04-01

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 4351723, 4353201, 435334, 4353432, C12P 2104, C12P 2106, C12N 1500, C12N 500

Patent

active

056164726

ABSTRACT:
Recombinant DNA vectors which express chimeric T cell receptors are disclosed. These chimeric T cell receptors contain one human element, and the rest of the elements are all of the same, non-human animal species, such as a mouse. Of particular interest are chimeras where the human element is V.alpha. or V.beta.. The vectors are used to transfect cells which derive from the same non-human animal species as the non-human animal species of the chimera, and the resulting transfectants are used to produce monoclonal antibodies against the human element of the chimera.

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