Process for producing microparticles

Details Process for producing microparticles Process for producing microparticles

2011-04-12

2011-04-12

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C264S004100

Reexamination Certificate

active

07923034

ABSTRACT:
An object of the present invention is to provide a solvent which is able to produce microparticles where content of the drug is still high and no initial burst takes place even when a drug having a low solubility in a halogenated hydrocarbon solvent is used. The present invention provides a process for production by a solvent-evaporation microencapsulation method, of microparticles which are composed of biodegradable polymer and contain a drug having a low solubility in a halogenated hydrocarbon, which is characterized in that the drug and the biodegradable polymer are dissolved in a mixed solvent comprising a first solvent: halogenated hydrocarbon, and a second solvent: a water-immiscible organic solvent in which solubility of the above-mentioned drug is 0.3% (w/v) or more.

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