Process for producing lactol-type cephalosporins

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424246, C07D51514

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active

039844013

ABSTRACT:
A 3-hydroxymethylcephalosporin which is not protected at the carboxyl group can be directly oxidized with a hexavalent chromium compound to give in good yield a lactol type cephalosporin represented by the general formula: ##SPC1##
Wherein R.sup.1 is hydrogen or an alkoxy group and R.sup.2 is an acylamino, or imido group. The resulting compounds are very useful and important as intermediates for preparing, e.g. 3-alkoxyiminomethyl cephalosporins.

REFERENCES:
patent: 3351596 (1967-11-01), Chamberlin
patent: 3682903 (1972-08-01), Bickel
Houben-Weyl, Methoden Der Organischen Chemie, Band VI/2, 1963, p. 716.

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