Process for producing L-isoleucine and ethionine by isoleucine a

Details Process for producing L-isoleucine and ethionine by isoleucine a Process for producing L-isoleucine and ethionine by isoleucine a

1992-11-09

1994-11-08

Knode, Marian

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

4352528, 435849, C12P 1306

Patent

active

053626370

ABSTRACT:
Disclosed is a process for producing L-isoleucine which comprises culturing in a medium a microorganism belonging to the genus Escherichia and having resistance to an isoleucine analogue and either ethionine or argonine hydroxamate and an ability to produce L-isoleucine until L-isoleucine is accumulated in the culture, and recovering L-isoleucine therefrom.

REFERENCES:
patent: 5017483 (1991-05-01), Furukawa et al.
patent: 5087566 (1992-02-01), Takano et al.
Kisumi et al., "Properties of Isoluecine Hydroxamate-Resistant Mutants of Serratia marcescens", J. of Gen. Microbiol., vol. 69, pp. 291-297 1971.
Nakamura, et al., Chem. Abs, 89(17):462 (1978).
Komatsubara et al., 1980, "Transductional Construction of an Isoleucine-producing Strain of Serratia marcescens", J. Gen. Microbiol., 119:51-61.
Kisumi et al., 1977, "Enhancement of Isoleucine Hydroxamate-Mediated Growth Inhibition and Improvement of Isoleucine-Producing Strains of Serratia marcescens", App. and Environ. Microbiol., 34(6):647-653.
Kase and Nakayama, 1977, "L-Isoleucine Production by Analog-resistant Mutants Derived from Threonine-producing Strain of Corynebacterium glutamicum", Agric. Biol. Chem., 41(1):109-116.
Ikeda et al., 1976, "Screening of L-Isoleucine Producers among Ethionine Resistant Mutants of L-Threonine Producing Bacteria", Agr. Biol. Chem., 40(3):511-516.
Kisumi et al., 1972, "Isoleucine Accumulation by Regulatory Mutants of Serratia marcescens: Lack of Both Feedback Inhibition and Repression", J. Bacteriol., 110(2):761-763.
Szentirmai et al., 1968, "Isoleucine and Valine Metabolism of Escherichia coli", J. Bacteriology 95(5):1672-1679.

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