Process for producing kampo medicine hard capsules

Details Process for producing kampo medicine hard capsules Process for producing kampo medicine hard capsules

1992-09-08

1994-06-07

Lovering, Richard D.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

424452, 424456, 514962, 514974, A61K 948, B01J 1302

Patent

active

053187989

ABSTRACT:
When a powdered extract of Kampo medicine is encapsulated as such in hard capsules, the pharmaceutical effects of the Kampo medicine cannot be fully achieved, since the dissolution of the content of the hard capsules requires a long period of time. Therefore, the present invention aims at providing Kampo medicine hard capsules having good dissolution properties.
The present invention provides a process for producing Kampo medicine hard capsules which comprises compacting Kampo medicine extract powder, mixing magnesium stearate with the compacted Kampo medicine extract powder and filing the mixture into gelatin hard capsules.
It is preferable that the weight ratio of the magnesium stearate to the Kampo medicine powdered extract ranges from 0.5/100 to 3/100. Furthermore, it is preferable that said Kampo medicine is selected from Oren-gedoku-to, Sho-saiko-to, Ninjin-to, San'o-shashin-to, Mao-bushi-saishin-to, Anchu-san, Keishi-bukuryo-gan, Byakko-ka-ninjin-to, Shakuyaku-kanzo-to and Sairei-to.

REFERENCES:
patent: 3780065 (1973-12-01), Sutton
patent: 3909444 (1975-09-01), Anderson et al.
patent: 3915955 (1975-10-01), Cooper et al.
patent: 3943238 (1976-03-01), Kobayashi et al.
patent: 4719228 (1988-01-01), Rawlins
patent: 4806659 (1989-02-01), Itsuo et al.
patent: 5221289 (1993-06-01), Miyamatsu et al.
Nakagawa et al., "Effects of Particle Size of Rifampicin and Addition of Magnesium Stearate on Release of Rifampicin from Hard Gelatin Capsules," Yakugaku Zasshi, 11 (11) 1111-1117 (1980).
J. Pharm. Phrmac., The Effect Of Additives On The Release Of Drug From Hard Gelatin Capsules, vol. 23, pp. 452-453.

Affiliated with

Also associated with

Rating

Process for producing kampo medicine hard capsules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing kampo medicine hard capsules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing kampo medicine hard capsules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-791537