Process for producing isoxazole derivatives

Details Process for producing isoxazole derivatives Process for producing isoxazole derivatives

1993-09-16

1994-05-10

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26108

Patent

active

053109260

ABSTRACT:
The present invention provides a process for producing isoxazole derivatives represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each a hydrogen atom or lower alkoxyl, and R.sup.3 is cyano or alkoxycarbonyl, the process being characterized by oxidizing an .alpha., .beta.-unsaturated ketoxime derivative represented by the formula ##STR2## wherein R.sup.1 , R.sup.2 and R.sup.3 are as defined above. The isoxazole derivatives (II) to be produced by the process of the present invention are useful as intermediates for preparing (3,4-diarylisoxazol-5-yl) acetic acid derivatives which are useful as anti-inflammatory agents, analgesics and antipyretics.

REFERENCES:
patent: 5142091 (1992-04-01), Tanaka et al.
CA 110(21):192690j Synthesis . . . acid. Yamawaki et al., p. 737, 1989.
CA 113(13):108936a General . . . drug. Effect . . . system. Yamamoto et al., p. 39, 1990.
CA 114(5):42776k Preparation . . . isoxazolylacetates, Hagiwara et al., p. 744, 1991.

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