Process for producing intravenous immune globulin

Details Process for producing intravenous immune globulin Process for producing intravenous immune globulin

1976-11-26

1978-02-21

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, A23J 106, A61K 3514

Patent

active

040751937

ABSTRACT:
A process is provided for producing intravenous immune globulin which comprises adsorbing plasminogen from blood of a selected mammalian species on L-lysine agarose, washing the adsorbate and eluting the purified plasminogen, converting the plasminogen to plasmin, and incubating a mixture of the plasmin and homospecific immune globulin having anticomplementary activity so as to reduce the anticomplementary activity, adsorbing excess plasmin present in the mixture, and recovering the immune globulin from the mixture.

REFERENCES:
patent: 3449316 (1969-06-01), Querry
patent: 3808124 (1974-04-01), Dziobkowski et al.
patent: 3943245 (1976-03-01), Silverstein
patent: 3966906 (1976-06-01), Schultze et al.
Deutsch et al., Science, vol. 170, pp. 1095-1096 (1970).
Liu et al., Can. J. Biochem., vol. 49, pp. 1056-1061 (1971).

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