Process for producing intermediate furanones from diol derivativ

Details Process for producing intermediate furanones from diol derivativ Process for producing intermediate furanones from diol derivativ

1985-07-10

1986-06-24

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 18, 549319, C07D32710, C07D30732

Patent

active

045968799

ABSTRACT:
A novel process for the manufacture of the furanone of the formula ##STR1## is described. In this process, a diol is firstly reacted with thionyl chloride, then the sulphite formed, optionally after oxidation to the corresponding sulphate, is treated with sodium cyanide and the resulting hydroxynitrile is hydrolyzed.
The furanone of formula I can be used as a starting material for the manufacture of R-(-)-pantolactone.

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Doyle et al., Synthetic Comm., 10, 881 (1980).
Tomioka et al., Tet. Letters, 1605 (1981).

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