Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1983-05-05
1984-09-04
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
A61K 3578
Patent
active
044696850
ABSTRACT:
A process for producing interferon inducers from the plants, comprising extracting a water-soluble interferon inducer with water from the tissue of a plant selected from the genera Atractylodes, Lonicera, Plantago, Lithospermum, Ligusticum, Cnidium, Bupleurum, Notopeterygium, Heracleum, Aralia, Panax, Polygala, Sophora, Euchresta, Astragalus, Sinomenium, Stephania, Cocculus, Cimicifuga, Rheum, Gastroida, Asparagus, Pinellia, Evoida and variants thereof capable of producing said interferon inducer at a temperature of from ambient to the boiling point of the extraction mixture for a period sufficient to extract the major portion of said interferon inducer present in the plant tissue, forming a supernatant, fractionating the supernatant to yield fractions containing the major portion of said interferon inducer in the supernatant and recovering said interferon inducer therefrom. Preferably, the fractionation may be effected by ultrafiltration. The interferon inducers thus obtained have a molecular weight of from about 30,000 to about 3,000,000 and are of potential interest for preventing and treating various diseases of humans and animals caused by viral infection.
REFERENCES:
patent: 3852423 (1979-12-01), Nakase et al.
Finter, Interferons and Interferon Inducers, pp. 13-17, 139 and 140, North-Holland Pub. Co., 1973.
Hashimoto Takashi
Kojima Yasuhiko
Konno Seishi
Tamamura Sadao
Friedman Stanley J.
Rollins Jr. John W.
The Kitasato Institute
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