Process for producing interferon

Details Process for producing interferon Process for producing interferon

1978-07-14

1980-08-05

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 4502

Patent

active

042162033

ABSTRACT:
Interferon is produced by incubating cells, which are susceptible to producing interferon, prior to induction by an inducer, in a medium containing an effective non-toxic amount of a straight chain, saturated carboxylic acid or a salt thereof.

REFERENCES:
W. Rutter et al., Ann. Rev. Biochem, 42, 601-646 (1973).
F. N. Reizin et al., Antibiotiki (Moscow), 21 (1), pp. 45-48 (1976) English Translation.
R. Henneberry et al., Exp. Cell Reserach, 103, pp. 55-62 (1976).
R. Kameji et al., J. Biochem., 81, 1901 (1977).
P. Marks et al., Ann. Rev. Biochem., 47:419-448 (1978).
Strander et al., J. Clin, Mocrobiol. (1975), 1, 116-117.
Wright et al., J. of the Nat'l. Cancer Institute, (1974), 53, 1, 271-275, Interferon Production by Simian Lymphoblastoid cell lines.
Tovey et al., Nature, (1977), 267, 455-457.
Wright, Exp. Cell Res. (1973), 78, 456-460.
Deutsch et al., J. Cell Sci., (1976) 21, 391-406.
Simmons et al., J. Cell Biol. (1975), 66, 414-424.
Leder et al., Science (1975), 190, 893-894.
Ginsburg et al., Proc. Natl. Acad. Sci. USA (1973) 70, 2457-2461.

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