Process for producing immunosuppressives and a novel microbial s

Details Process for producing immunosuppressives and a novel microbial s Process for producing immunosuppressives and a novel microbial s

1993-02-22

1995-04-25

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435711, 4352541, 514 11, 530317, 530321, C12P 2104, C12N 114, A61K 3700, A61K 3702

Patent

active

054098165

ABSTRACT:
The invention relates to a process for producing a cyclosporin, especially cyclosporin A, by cultivating the strain (LEA3) of the novel Tolypocladium species aerobically at a temperature of 20.degree.-30 .degree. C. in a nutrient medium containing carbon sources, nitrogen sources and mineral salts, and, if desired, isolating and purifying the resulting cyclosporin.

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Agathos et al, Journal of Industrial Microbiology, 1 (1986) 39-48, Physiological and genetic factors for process development of cyclosporine fermentations.

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