Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1991-07-23
1993-12-21
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435117, 4352535, 435898, C12P 1718, C12P 1700, C12N 120
Patent
active
052720683
ABSTRACT:
Described is a new process for producing the immunosuppressant, L-683,742, a C-31 demethylated, derivative of L-683,590 (FK-520), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 3094460 (1963-06-01), DeBoer
patent: 3244592 (1966-04-01), Arai
J. Antibiotics, A15, pp. 231-232, by Arai, et al.
Arison Byron H.
Danis Susan J.
Ruby Carolyn L.
Marx Irene
Merck & Co. , Inc.
North Robert J.
Pfeiffer Hesna J.
Thies J. Eric
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