Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-07-28
1994-06-28
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435132, 435147, 435155, 435170, C12P 1718, C12P 700, C12P 724, C12P 702
Patent
active
053246446
ABSTRACT:
Described is a new process for producing the immunosuppressant, L-682,993, a C-31 demethylated derivative of L-679,934 (FK-506), produced under fermentation conditions utilizing the new mutant microorganism Streptomyces sp. (Merck Culture Collection MA 7017) ATCC No. 55334, being a blocked second generation mutant of Streptomyces sp. (MA 6858) ATCC No. 55098. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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J. Antibiotics, 15, pp. 231-232 (1962), by T. Arai, et al., entitled Ascomycin, an Antifungal Antibiotic.
Seiichi et al., Chemical Abstracts, 116(11): 104486t, 1992.
Arison Byron H.
Chung Christine C.
Ruby Carolyn L.
Caruso Charles M.
Merck & Co. , Inc.
Osoteo Maria L.
Robinson Douglas W.
Thies J. Eric
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