Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-11-27
1993-02-09
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
426 43, 435 681, 514885, 530322, 530825, A61K 3718, C07K 112, C12P 2106, A23C 2108
Patent
active
051853213
ABSTRACT:
Immunostimulant products are prepared by adding lysozyme to a culture of L.bulgaricus at a pH of from 4-8 and then incubating the culture to hydrolyze peptidoglycans of cell walls of the bacteria. A suspension containing the lysozyme-treated L.bulgaricus is collected, which is centrifuged to obtain an immunostimulant supernatant. The supernatant may be filtered to obtain an immunostimulant solution, which may be added to a fermented milk, or to a whey, to prepare an immunostimulant product. Alternatively, L.bulgaricus may be cultured and hydrolyzed by lysozyme in a milk product to provide an immunostimulant milk product.
REFERENCES:
patent: 3762998 (1973-10-01), Bogdanov
patent: 4501693 (1985-02-01), d'Hinterland et al.
patent: 4515891 (1985-05-01), Yokegawa et al.
Pahud et al, "Calf rennet lysozyme" Biochem. J., vol. 201, 1982, pp. 661-664.
Kuwana, et al. "Effect of Lytic Enzyme on Protoplast Formation of Lactic Acid Bacteria" Seikatsu Eisei (Life and Hygiene), vol. 31(2) 1987, pp. 32-41 (with translation).
Neviani, et al., "Sensitivity of Lactic Bacteria to Lysozyme" L'Industria del latte 24(1), 1988 (with translation).
Nomoto, et al. "Augmentation of resistance of mice to bacterial infection by a polysaccharide-peptidoglycan complex (PSPG) extracted from Lactobacillus casei", Biotherapy. 1:169-177, 1989.
Link Harriet
Pahud Jean-Jacques
Nestec S.A.
Russel Jeffrey E.
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