Process for producing HMG-CoA reductase inhibitors

Details Process for producing HMG-CoA reductase inhibitors Process for producing HMG-CoA reductase inhibitors

2005-09-20

2005-09-20

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

C435S136000, C435S146000, C435S155000, C435S132000

Reexamination Certificate

active

06946270

ABSTRACT:
The present invention relates to a process for producing a compound (II-a) or a compound (II-b), each of which is a hydroxylated product of a compound represented by the formula (I-a) (hereinafter referred to as compound (I-a)):whereinR1represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2represents a substituted or unsubstituted alkyl, or a substituted or unsubstituted aryl;or a ring-closed lactone form thereof (hereinafter referred to as compound (I-b)).wherein the process comprises:treating the compound (I-a) or compound (I-b) in an aqueous medium comprising with a microorganism acting to hydroxylate compound (I-a) or compound (I-b), having no ability to sporulate and showing no hyphal growth, a culture of the microorganism, or a treated product of the culture, as an enzyme source; andcollecting a hydroxylated product of compound (I-a) or compound (I-b) from the aqueous medium.

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