Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Lyase
Patent
1982-01-08
1984-04-17
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Lyase
C12N 988
Patent
active
044435452
ABSTRACT:
Heparinase is produced by growing the bacterium, Flavobacterium heparinum in an improved defined medium consisting of a carbon source, two or more amino acids and several salts in the absence of protein. The carbon source concentration is specifically kept below a certain level to promote improved heparinase production. The sulfate source concentration is also specifically kept below a certain level to promote improved heparinase synthesis. Heparinase can be produced in this medium with or without the addition of an inducer compound.
REFERENCES:
patent: 3549500 (1970-12-01), Suzuki
Linker et al., Methods in Enzymology, vol. 28, pp. 902-911.
Applied and Environmental Microbiology, pp. 360-365 (Feb. 1981).
Cooney Charles L.
Galliher Parrish M.
Langer, Jr. Robert S.
Linhardt Robert
Engellenner Thomas J.
Massachusetts Institute of Technology
Shapiro Lionel M.
Smith, Jr Arthur A.
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