Process for producing halomethylcarbapenems

Details Process for producing halomethylcarbapenems Process for producing halomethylcarbapenems

1990-10-10

1991-11-12

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48704

Patent

active

050649540

ABSTRACT:
A functionallized intermediate for antibacterial carbapenems, 2-halomethylcarbapenem (III) is effectively synthesized by treating 2-hydroxymethylcarbapenem (I) with a phosphorylating reagent to give 2-phosphoryloxymethylcarbapenem (II) and then treating this product with a halogenating reagent. Some carbapenems derived from the intermediate are also disclosed. ##STR1## wherein, R.sup.1 is hydrogen or substituted or unsubstituted alkyl;

REFERENCES:
patent: 4298741 (1981-11-01), Christsen et al.
patent: 4310538 (1982-01-01), Christsen et al.
CA113:1149371 "Preparation of Azetidinone Intermediates for Carbapenems" Uyeo, Shoichiro (1990).

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