Process for producing glutamine derivative

Details Process for producing glutamine derivative Process for producing glutamine derivative

1997-04-04

1998-07-14

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C22900

Patent

active

057806772

ABSTRACT:
N-chloroacetylglutamine is produced by reacting chloroacetyl chloride with an alkaline aqueous solution of glutamine the presence of a water-immiscible organic solvent, separating an aqueous layer by liquid-liquid separation, and crystallizing N-chloroacetyl-glutamine from the aqueous layer under acidic conditions. N-Chloroacetyl-glutamine useful as an intermediate for producing glycyl-L-glutamine which has higher stability than L-glutamine and is used as a component of an infusion solution can be obtained with high efficiency at low cost.

REFERENCES:
patent: 3206506 (1965-09-01), Griffith
patent: 5380934 (1995-01-01), Inoue
Hoppe-Seyler's Z. Physiol. Chem., 105, 58 (1919), Thierfelder et al.
J. National Cancer Inst., 7, 275 (1947), "Studies on the Effect of Pyruvate on the Desamidation et al" Price et al pp. 275-279.
Aust. J. Chem., 7, 173 (1954).

Affiliated with

Also associated with

Rating

Process for producing glutamine derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing glutamine derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing glutamine derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1883300