Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1998-10-07
2000-11-14
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C07C22924, C07C22900
Patent
active
06147259&
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a process for producing glutamic acid. More particularly, the present invention relates to an indirect acidulation process for the preparation of glutamic acid and monosodium glutamate (hereinafter referred to as MSG), from a glutamate-containing aqueous feed resulting from fermentation.
Many patents propose using ion exchangers in the separation of amino acids in general, and particularly for production of glutamic acid and mono-sodium glutamate. In some cases, the ion-exchangers are used for removal of anionic and cationic impurities. In others, glutamic species are bound on the resin. In basic medium glutamate carries one or two negative charges and can be bound to an anion exchanger. In strongly acidic solution (pH of about 2 or lower), the glutamate is positively charged and binds to cation exchangers.
U.S. Pat. Nos. 3,336,374 and 3,655,746; and GB 2,095,232 use cation and anion exchangers for removal of contaminants. In U.S. Pat. No. 3,015,655 nitrogenous organic compounds, including amino acids, are bound to a strongly acidic cation exchanger (SACE). British Patent 811,688 purifies solutions containing glutamic acid by ion-exchangers and then binds the glutamic acid to a weakly basic anion exchanger (WBAE), U.S. Pat. No. 5,279,744 uses SACE for binding glutamic acid in multiple-counter current stages. JP 94017346 separates giutamic acid on SACE with the improvement of adding urea to prevent the growth of amino acid crystals on the resin and to enable a smooth elution. U.S. Pat. No. 4,675,196 removes glutamic acid from amino acid mixtures, obtained on protein hydrolysis, by adsorption on a strong base anion exchanger (SBAE). U.S. Pat. No. 3,505,399 adsorbs glutamic acid from an acidic solution of pH=2.0-0.5 on a SACE and elutes it with alkaline solution. CN 91-104354 suggests adsorption of glutamic acid from crystallization mother liquor with an ammonium- type SACE and elution with ammonia water.
The glutamate adsorption steps are followed by elution with various eluants, typically mineral acids or bases, so that the eluted glutamic acid is obtained in its salt form, or in a mixture with another acid. The effluent from the elution step requires further treatment for recovery of the acid, or for purification of the salt.
According to GB 1201823, glutamic acid is recovered by passing a mother liquor (having a pH<4 from which some of the glutamic acid originally present has been crystallized and separated) through a strongly acidic cation exchange resin. Glutamic acid is adsorbed by the resin and is eluted with a fresh, glutamic acid containing fermentation broth. The eluate pH is adjusted to crystallize glutamic acid, which is then separated.
CH 401 987 teaches a process for the extraction and purification of glutamic acid from a liquid containing the same. Cationic impurities are eliminated by passing the liquid through a weakly acidic cation exchanger (WACE). Anionic and non-ionic impurities are separated by the use of a SACE. Glutamic acid is then eluted from the SACE with aqueous alkali; the pH is then adjusted and glutamic acid crystallised out.
SU 700803 suggests separation of the cells from the broth which is then passed through 2 columns of cation exchange resins and the glutamic acid is eluted with NH.sub.4 OH. The latter is passed through the first columns successively. The eluate is acidifed to pH=3.2 to separate crystals of glutamic acid. To increase the purity of the product, the eluate from the first column is cooled and acidified. The crystals of glutamic acid are separated and the solution is passed through the second column.
The eluate from the second column is treated in the same way and the crystals of glutamic acid separated in both steps are mixed together. Glutamic acid separated by crystallization in the first step is dissolved in NH.sub.4 OH solution (used for the regeneration of the ion exchangers) and recrystallized after evaporation and acidification of the solution. To simplify the regeneration of ion exchanger re sins a mineral acid was p
REFERENCES:
patent: 3015655 (1962-01-01), Stark et al.
patent: 3325539 (1967-06-01), Conklin et al.
patent: 3336374 (1967-08-01), Dobry
patent: 3505399 (1970-04-01), Samejima et al.
patent: 3639467 (1972-02-01), Nagal et al.
patent: 3655746 (1972-04-01), Shiraishi et al.
patent: 4675196 (1987-06-01), Villa et al.
patent: 5279744 (1994-01-01), Itoh et al.
Mitsubishi's Diaion Manual of Ion Exchange Resins and Synthetic Adsorbents (Mar. 1992), pp. 71-72.
Z. Jiang et al., "Recovery of Glutamic Acid from Fermentation Broth by Ion Exchange Process", Lizi Jiaohuan Yu Xifu 3(4) 35-9 (1987) No Month Provided.
Cami Pierre
Eyal Aharon
A. E. Staley Manufacturing Company
Amylum N.V.
Keys Rosalynd
Richter Johann
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