Process for producing fluoroalkoxyaminopyrimidines

Details Process for producing fluoroalkoxyaminopyrimidines Process for producing fluoroalkoxyaminopyrimidines

1984-03-27

1985-09-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544319, 544321, C07D23902

Patent

active

045422168

ABSTRACT:
A novel process for producing fluoroalkoxyaminopyrimidines of the formula I ##STR1## wherein R is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or benzyl, X is halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino, and T is hydrogen, chlorofluoromethyl, bromofluoromethyl, difluoromethyl or 1,2,2,2-tetrafluoroethyl, characterized in that a thiopyrimidine of the formula II ##STR2## wherein Y has the meaning given for X under the formula I or is hydroxyl, A is hydrogen, sodium, potassium or an equivalent of calcium or magnesium, and Q is C.sub.1 -C.sub.4 -alkyl, phenyl or benzyl, is reacted with difluorochloromethane, difluorobromomethane, tetrafluoroethylene, perfluoropropylene, trifluorobromoethylene or trifluorochloroethylene in the presence of a base; the resulting compound of the formula III ##STR3## is converted by oxidation into a compound of the formula IV ##STR4## wherein n is the number one or two; and this compound is treated with an amine of the formula V

REFERENCES:
patent: 4480101 (1984-10-01), Meyer
Pissiotas et al., Chem. Abst. 101:211162w (1984).
Meyer, Chem. Abst. 99:22486j, 98:215616q (1983).
Tamura et al., Chem. Abst. 83:2314t (1975).
Chem. Listy 52, 357 (1958), Jaroslav Stanek.

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