Process for producing fluoro-compounds

Details Process for producing fluoro-compounds Process for producing fluoro-compounds

2006-03-22

2009-11-10

Nazario-Gonzalez, Porfirio (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C560S227000, C560S100000, C560S111000, C560S124000, C560S145000, C549S518000

Reexamination Certificate

active

07615669

ABSTRACT:
The present invention provides a process for producing highly pure fluoro-compounds by making use of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products. The present invention provides a process for producing a fluoro-compound, comprising fluorinating an alcohol derivative represented by the following general formula (I): R1R2R3COH (I), (wherein R1represents a hydrogen atom, a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group; and R2and R3are each independently a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group, wherein at least two of R1, R2and R3may together form part of a ring structure, either with or without a heteroatom) with N,N-diethyl-2-chloro-1,1,2-trifluoroethylamine to form a fluoro-compound represented by the following general formula (2): R1R2R3CF (2), (wherein R1, R2and R3are as defined above), the process being characterized in that an alcohol derivative represented by the following general formula (3): R4OH (3), (wherein R4represents a substituted or unsubstituted alkyl group or aryl group) is added to the reaction system.

REFERENCES:
patent: 3929769 (1975-12-01), Kaufmann et al.
patent: 5780672 (1998-07-01), Pasenok et al.
patent: 2005/0085474 (2005-04-01), Ebenbeck et al.
patent: 1020541 (1977-11-01), None
patent: 2181134 (1997-01-01), None
patent: 596 238 (1978-03-01), None
patent: 2 324 158 (1973-11-01), None
patent: 195 25 727 (1997-01-01), None
patent: 103 00 112 (2004-07-01), None
patent: 0 753 497 (1997-01-01), None
patent: 1 437 342 (2004-07-01), None
patent: 2 185 619 (1974-01-01), None
patent: 1 427 761 (1976-03-01), None
patent: 49-41356 (1974-04-01), None
patent: 9-48741 (1997-02-01), None
patent: 2004-231646 (2004-08-01), None
patent: 7306923 (1973-11-01), None
Hudlicky, M., (Sterospecific synthesis of all four stereoisomers of 4-fluoroglutamic acid, 1993, Journal of Fluorine Chemistry, 60 (2-3), pp. 193-210 (abstract 3 pages).
Edited by CSJ: The Chemical Society of Japan, ‘Shin Jikken Kagaku Koza 14 Yuki Kagobutsu no Gosei to Hanno I’, Maruzen Co., Ltd., pp. 310-311, Nov. 20, 1977.
International Search Report issued May 30, 2006 in the International (PCT) Application of which the present application is the U.S. National Stage.

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