Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1991-01-28
1992-05-26
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435118, 435886, C12R 1465, C12P 1716
Patent
active
051167565
ABSTRACT:
Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 3244592 (1966-04-01), Arai
patent: 4894366 (1990-01-01), Okuhara et al.
J. Antibiotics A15: 231-232 (1962).
Dumont Francis
Fernandez Isabel M.
Garrity George M.
Matas Teresa D.
Caruso Charles M.
Lilling Herbert J.
Merck & Co. , Inc.
North Robert J.
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