Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1991-10-07
1993-03-16
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352535, 435886, C12P 1716, C12P 1465
Patent
active
051943786
ABSTRACT:
Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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Arai, et al., Ascomycin, An Antifungal Antibiotic, J. Antibiotics, A15, pp. 231-232 (1962) (Cumulative).
Dumont Francis
Fernandez Isabel M.
Garrity George M.
Huang Leeyuan
Jones E. Tracy T.
Caruso Charles M.
Lilling Herbert J.
Merck & Co. , Inc.
Mitri Salvatore C.
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