Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-02-21
1997-07-01
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530427, 530830, 530418, C07K 114, C07K 130, C07K 1475
Patent
active
056440324
ABSTRACT:
A process for producing a fibrinogen concentrate for use as a tissue adhesive from mammalian plasma includes freezing the plasma to a temperature of at most about -20.degree. C. for less than four hours in a container having a surface to volume ratio of from about 4.38:1 to about 1.65:1 reciprocal centimeters, thereby producing frozen plasma; thawing the frozen plasma at a temperature of at least about 4.degree. C. for a time sufficient to attain about 5% to about 95% residual icing, thereby producing thawed plasma; and centrifuging the thawed plasma to produce a fibrinogen concentrate having a solids content of about 6% to about 44% solids by weight of the concentrate.
REFERENCES:
patent: 2492458 (1949-12-01), Bering et al.
patent: 3523807 (1970-08-01), Gerendas et al.
patent: 4251437 (1981-02-01), Rasmussen et al.
patent: 4278592 (1981-07-01), Seufert et al.
patent: 4289691 (1981-09-01), Rock et al.
patent: 4298598 (1981-11-01), Schwarz
patent: 4359049 (1982-11-01), Redl et al.
patent: 4362567 (1982-12-01), Schwarz et al.
patent: 4377572 (1983-03-01), Schwarz et al.
patent: 4414976 (1983-11-01), Schwarz et al.
patent: 4427650 (1984-01-01), Stroetmann
patent: 4600574 (1986-07-01), Lindner
patent: 4608254 (1986-08-01), Philapitsch
patent: 4627879 (1986-12-01), Rose et al.
patent: 4631055 (1986-12-01), Redl et al.
patent: 4650678 (1987-03-01), Fuhge et al.
patent: 4735616 (1988-04-01), Eibl
patent: 4909251 (1990-03-01), Seelich
patent: 4928603 (1990-05-01), Rose et al.
patent: 4960757 (1990-10-01), Kumpe et al.
patent: 5321126 (1994-06-01), van Dommelen et al.
patent: 5420250 (1995-05-01), Lontz
Anonymous, Freezing and Thawing Serum Cells, Technical Bulletin, Art to Science, vol. 5, No. 2, HyClone Laboratories, Logan, Utah. 1986.
ASTM Designation D-413--82 Standard Test Methods for Rubber Property--to Flexible Substrate, pp. 70, 71, 73 and 74. 1990.
ASTM Designation F-639--79:85 Standard Specification for Polyethylene Plastics for Medical Applications, p. 164, 1990.
ASTM Designation D-638--68 Standard Method of Test for Tensile Properties of Plastics, pp. 189, 195-197, 1990.
Brands et al., Preservation of the Ruptured Spleen by Gluing with Concentrated Fibrinogen. Experimental and Clinical Results. World J. Surg., vol. 6, 1982 366-368.
Brodniewicz-Proba et al., Modified Glycine Precipitation Technique for the Preparation of Factor VIII Concentrate of High Purity and High Stability Vox-Sang 1987 52:10-14.
Castillo et al., Prothrombin Times and Clottable Fibrinogen Determination on An Automated Coagulation Laboratrory. Thrombosis Res., 1989 213-219.
Cohn et al., Preparation and Properties of Serum and Plasma Proteins. IV. A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids J. Am. Chem. Soc. 68:459-475. 1946.
Conte et al., Infection-Control Guidelines for Patients with the Acquired Immunodeficiency Syndrome (AIDS), The New Eng. Jour. of Med 1983 740-744.
Dresdale et al., Hemostatic Effectiveness of Fibrin Glue Derived from Single-Donor Fresh Plasma. Ann. Thor. Surg. 1985 40:385-387.
Dresdale et al., Preparation of Fibrin Glue from Single-Donor Fresh-frozen Plasma, Surgery 1985 97:750-754.
Edsall et al., Effects of Ions and Neutral Molecules on Fibrin Clotting J. Biol. Chem. 1951 191:735-756.
Epstein, et al., Current Safety of Clotting Factor Concentrates Arch. Pathol. Lab. Med. 1990 114:335-340.
Espstein, G. H. et al., A New Autologous Fibrinogen-Based Adhesive for Otologic Surgery. Ann. Otol. Rhinol Laryngol, 1986 95:40-45.
Fennema, O., Behaviour of Proteins at Low Temperatures. Food Protein Preservation. Mechanism and Funtionality. Am. Chem. Soc. Series 209, 1982 109-135.
Farrugia et al., "Studies on the procurement of blood coagulation factor VIII effects of plasma freezing rate and storage conditions on cryoprecipitate quality", J. Clin. Pathol. 1985 38:433-437.
FDA Drug Bulletin vol. 8, No. 2, pp. 15-16, Mar. Apr. 1978.
Gestring, Gidon F., Autologous Fibrinogen for Tissue-Adhesion, Hemostasis and Embolization Vascular Surgery 1982 294-296, and 303.
Grey, R.G. Fibrin as a Hemostatic in Cerebral Surgery. Surg. Gynecol. Obstr. 1915 21:452-454.
Holmes et al., Studies of a-Proteins in Human Cell Cult., In Vitro, 1979 15:522-530.
Klein, J., The Interdiffusion of Polymers, Science, 1990 250:640-641.
Kram, H.B., et al., "Fibrin Glue Sealing of Polyetetrafluoroethylene Vascular Graft Anastomoses. Comparison with Oxidized Cellulose", J. Vascular Surgery, 1988, 8:563-568.
Putnam, Frank W., Ed. The Plasma Proteins, Ch. 2. vol. 1, Pennell, Robert B. Fractionation and Isolation of Purified Components by Precipitation Methods, pp. 9-50 1960.
Putnam, F.W., Ed. The Plasma Proteins, 2nd Ed., Section 3. Doolittle, R.F., Fibrinogen and Fibrin pp. 108-160, 1975.
Putnam, F.W., Ed. The Plasma Proteins, 2nd Ed., Section 4. Clamp, J.R. Structure and Functions, pp. 136-141, 163-211, 1975.
Siedentop et al., Autologous Fibrin Tissue Adhesive, Laryngoscopy, 1985 95:1074-1076.
Spotnitz et al., Fibrin Glue from Stored Human Plasma, The American Surgeon 1987 No. 8:460-462.
Cucuianu et al. Rev. Chir. Oncol. Radiol. O.R.L. Oftalmol. Stomatol. Sec. Oto-Rino-Laringologia 1988 33:81-88 and English Translation.
Lozina-Lozinski, Studies in Cryobiology, 195-203 John H. Wiley & Sons, New York. (No date).
The Lancet, issued 01 Jul. 1978, Mason, "Thaw-Siphon Technique for Production of Cryoprecipitate Concentrate of Factor VIII", pp. 15-17.
Fibrin Corporation
Russel Jeffrey E.
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