Process for producing etoposide

Details Process for producing etoposide Process for producing etoposide

1986-09-08

1988-07-12

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536115, 536120, C07H 1524

Patent

active

047571381

ABSTRACT:
The present invention relates to a process for producing etoposide by reacting a 4'-halogenoacetyl-4'-demethylepipodophyllotoxin-.beta.-D-2,3-di-O-halogeno acetyl-4,6-O-ethylideneglucoside represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, represent each --COCHX.sub.2 or --COCX.sub.3, wherein X represents a halogen atom, with an alcohol, an amine, and/or ammonia to remove the halogenoacetyl groups.

REFERENCES:
patent: 4564675 (1986-01-01), Kurabayashi et al.
Chemical Abstracts, vol. 101, No. 3, Jul. 1984, p. 639, No. 23883h, Columbus, Ohio.
Chemical Abstracts, vol. 100, No. 21, May 1984, p. 670, No. 175210d, Columbus, Ohio.
EP-A-O 111 058 (Nippon Kayaku K.K.), p. 7, III-I, pp. 18, 20, claim 10.
Protective Groups in Organic Synthesis (T. W. Greene) (1982), pp. 55 and 56.

Affiliated with

Also associated with

Rating

Process for producing etoposide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing etoposide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing etoposide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-665156