Process for producing etoposide

Details Process for producing etoposide Process for producing etoposide

1996-12-04

1998-10-13

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 181, 536 185, C07H 100

Patent

active

058213481

ABSTRACT:
A protected 4'-demethyl-4-epipodophyllotoxin is reacted with a protected glucose derivative in a non-halogen type organic solvent in a 0.1-7-fold parts by volume based on 1 part by weight of the protected 4'-demethyl-4-epipodophyllotoxin to give an etoposide derivative of formula (3) which is protected at its functional groups: ##STR1## wherein each of R.sub.1 and R.sub.2 each is a protective group for hydroxy, if necessary, followed by removal of these protective groups. By use of the non-halogen type organic solvent in lieu of any harmful halogen type solvent, formation of undesirable by-products can be minimized so that the etoposides can be obtained in a high yield and high purity.

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