Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1979-07-12
1981-05-12
Helfin, Bernard
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
260456P, 585400, 260456R, 424340, 424356, 424353, 568323, 568316, 568807, 570193, C07C 4118, C07C 4124, C07C 2518, C07C 2524
Patent
active
042673887
ABSTRACT:
There is disclosed a novel process for preparing anti-inflammatory ethynylbenzene derivatives represented by the general formula I: ##STR1## wherein Y is hydrogen, halogen or loweralkyl of 1 to 3 carbon atoms; R represents a ring having the structure: ##STR2## wherein x is 1 to 3, or a ring of the structure: ##STR3## wherein Y' is hydrogen, halogen, loweralkyl of 1 to 3 carbon atoms and loweralkoxy of 1 to 3 carbon atoms; Y" is hydrogen or halogen; and Y"' is hydrogen or halogen, provided Y, Y', Y" and Y"' are not all hydrogen at the same time, by reacting a benzyl alcohol of formula V: ##STR4## with a sulfonyl chloride, reducing the sulfonate VI of the formula: ##STR5## and dehydrohalogenating the formed .beta.-halostyrene of the formula VII: ##STR6##
REFERENCES:
patent: 2060303 (1936-11-01), Groll et al.
patent: 3435075 (1969-03-01), Glamkowski et al.
patent: 3981932 (1976-09-01), Diamond
patent: 4016214 (1977-04-01), Douglas et al.
patent: 4094995 (1978-06-01), Diamond
Campbell Henry F.
Darkes Paul R.
Douglas George H.
Helfin Bernard
Lezdey John
Miller Austin R.
Nicholson James A.
William H. Rorer, Inc.
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