Process for producing .epsilon.-poly-L-lysine with immobilized S

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide

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43525235, 435174, C12P 2104

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active

059003634

ABSTRACT:
An effective process for producing .epsilon.-poly-L-lysine is provided, which process comprises cultivating a microorganism having .epsilon.-poly-L-lysine productivity, such as a bacterium belonging to the Streptomyces genus, in the form of immobilized bacterial cells under aerobic conditions, and according to which process, the bacterial cells cause no bacteriolysis; the immobilized bacterial cells retaining .epsilon.-poly-L-lysine productivity can be easily separated and recovered from the culture solution containing .epsilon.-poly-L-lysine; and semi-continuous or continuous production of .epsilon.-poly-L-lysine by the use of the immobilized bacterial cells is possible.

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Heinrich et al, European J. Appl. Microbiol. Biotechnol. 15:88-92 (1982).
Mattiasson, Immobilized Cells and Organelles, vol. 1, CRC Press, Inc. : Boca Raton, Florida, (1983), pp. 8-13.
Shima et al., Agric. Biol. Chem., 45(11):2497-2502, (1981).
Shima et al, Agric. Biol. Chem, 45(11):2497-2502, (1981).
Hartmeier, Immobilized Catalysts, Springer-Verlag: New York, 1988, p. 45.

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