Process for producing diadenosine tetraphosphate and derivatives

Details Process for producing diadenosine tetraphosphate and derivatives Process for producing diadenosine tetraphosphate and derivatives

1987-05-28

1989-12-12

Griffin, Ronald W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 90, 435194, 435822, 435832, C12P 1936, C12N 912, C12R 101, C12R 107

Patent

active

048867497

ABSTRACT:
A process for producing diadenosine tetraphosphate or derivatives thereof in very high yields with little formation of undesired by-products is disclosed. The process comprises reacting adenosine-5'-triphosphate or a derivative thereof with an amino acid under the catalytic action of an aminoacyl-tRNA synthetase in the presence of an enzyme that converts adenosine-5'-diphosphate to adenosine-5'-triphosphate. The formation of by-products can be substantially completely inhibited if the last-mentioned enzyme is used in combination with an enzyme that converts adenosine-5'-monophosphate to adenosine-5'-diphosphate.

REFERENCES:
patent: 4331762 (1982-05-01), Nakajima et al.
patent: 4349631 (1982-09-01), Kagayama et al.
patent: 4572894 (1986-02-01), Imahori et al.
patent: 4584272 (1986-04-01), Imahori et al.
Goerlich et al., Eur. J. Biochem. 126:135-142 (1982).
Eur. Patent Application No. 0084975-Imahori et al. 3-08-83.
Barker, Eur. J. Biochem. 125:357-360 (1982).

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