Process for producing defatted heparin tissue for heparin produc

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Treating animal or plant material or micro-organism

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435 84, 536 21, C12B 100, C08B 3710

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active

041929160

ABSTRACT:
An improved process for producing defatted heparin tissue is disclosed wherein frozen heparin-bearing tissue is particulated, thawed and warmed in a heat exchanger, fermented at temperatures ranging from about 60.degree.-85.degree. F. for 5 to 12 hours and subjected to azeotropic distillation and extraction to substantially remove water and fat. Putrefaction and odor are avoided, the tissue has improved uniformity in biochemical content, is lower in fat content and is capable of high heparin yields when processed according to known procedures. The defatted tissue is exceptionally permeable to heparin recovery solutions and heparin isolation is facilitated.

REFERENCES:
patent: 2410084 (1946-10-01), Kuizenga
patent: 2539544 (1951-01-01), Levin et al.
patent: 2884358 (1959-04-01), Bush et al.
patent: 3862003 (1975-01-01), Okuyama et al.

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