Process for producing corosolic acid

Details Process for producing corosolic acid Process for producing corosolic acid

2006-07-04

2006-07-04

Oh, Taylor Victor (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C562S498000

Reexamination Certificate

active

07071229

ABSTRACT:
This invention provides an improved process for producing corosolic acid starts from ursolic acid, which occurs in plants in relatively large amounts, the method comprising the steps of oxidizing the hydroxyl group at 3-position and utilizing the carbonyl group at 3-position to introduce a hydroxyl group stereospecifically into the 3-oxoursolic acid at the 2α-position adjacent to the hydroxyl group at 3-position.

REFERENCES:
patent: 6485760 (2002-11-01), Matsuyama
patent: 1 022 022 (2000-07-01), None
patent: 2000-169384 (2000-06-01), None
patent: 2002-205949 (2002-07-01), None
C. Murakami et al., Chem. Pharm. Bull. 41(12), pp. 2129-2131 (1993).
Z. Z. Liang et al., Planta Med., vol. 56, pp. 330-332 (1990).

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