Process for producing controlled porosity microcapsules

Compositions – Preservative agents – Anti-corrosion

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424 32, 424 85, 424 94, 424DIG7, B01J 1302

Patent

active

043223117

ABSTRACT:
A process for producing microcapsules of controlled porosity containing a chemically active core material. A core material such as a biologically active material and a first monomer in aqueous solution are emulsified in a hydrophobic solvent. A monomer complementary to the first and soluble in the continuous, hydrophobic phase of the emulsion is added to initiate interfacial polymerization about the aqueous droplets. During the course of the reaction, the affinity of the continuous phase for the first monomer is varied by adding a solvent to the continuous phase to vary its polarity. The continuous phase may be relatively nonpolar at the outset and a polar solvent may be added to increase its affinity for the first monomer, or it may be relatively polar at the outset and a nonpolar (or less polar) solvent may be added. This technique allows production of microcapsules having a selected pore size so that, for example, encapsulated material cannot escape, yet lower molecular weight materials can diffuse through the capsule wall.

REFERENCES:
patent: 3429827 (1969-02-01), Ruus
patent: 3577515 (1971-05-01), Vandegaer
patent: 3864275 (1975-02-01), Kan et al.
patent: 4251387 (1981-02-01), Lim et al.

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