Process for producing compounds containing a terminal hydroxyl o

Details Process for producing compounds containing a terminal hydroxyl o Process for producing compounds containing a terminal hydroxyl o

1988-01-14

1991-07-16

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435157, 4351723, 43525234, 435281, C12P 1702

Patent

active

050325124

ABSTRACT:
This invention relates to a process for the microbiological production of compounds containing a terminal hydroxyl or epoxy group from an aliphatic substrate or a substrate with an aliphatic side chain, using microorganisms genetically engineered so that they have retained their capacity to perform the terminal oxidation of the substrate, but are no longer able to convert the resulting oxidation product further to any significant extent. Preferred substrates are n-alkanes, n-alkenes, and n-alkadienes containing 6-12 carbon atoms. Preferred micro-organisms are genetically engineered Pseudomonas oleovorans and Pseudomonas putida strains lacking an active plasmidic alkanol-dehydrogenase gene. The invention also relates to micro-organisms thus genetically engineered.

REFERENCES:
patent: 3813316 (1974-05-01), Chakvabarty et al.
Chakrabarty et al., 1971 Genetics, 68, No. 1, p. 510.
M. J. de Smet, A Biological Approach to the Synthesis of Epoxides, Thesis, 1982 Rijksuniversiteit Gronigen de Smet et al., Enzyme Microb. Technol. 5 (1983), pp. 352-360.
Witholt et al., TIBtech, 8, 46-52 (1990).
Chem. Abst. vol. 105, No. 3, No. 1979 6x (1986).
Chem. Abst. vol. 105, No. 1, No. 5162a (1986).

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