Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Reexamination Certificate
2008-01-22
2008-01-22
Prouty, Rebecca (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
C536S023200, C435S320100, C435S252300, C435S252330, C435S194000
Reexamination Certificate
active
07320883
ABSTRACT:
The invention aims at providing a process for producing coenzyme Q10efficiently in microorganisms by utilizing a coenzyme Q10side chain synthesis gene derived from a fungal species belonging to the genusAspergillusand genusLeucosporidium.The present invention relates to a DNA having a DNA sequence described under SEQ ID NO:1 and 2 or derived from the above sequence by deletion, addition, insertion and/or substitution of one or several bases and encoding a protein having decaprenyl diphosphate synthase activity.
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Koyama, T., et al., Thermostable Farnesyl Diphosphate Synthase ofBacillus stearothermophilus: Molecular Cloning, Sequence Determination, Overproduction, and Purification,J. Biochem., vol. 113, No. 3, pp. 355-363 (1993).
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Suzuki, K., et al., “Analysis of the Decaprenyl Diphosphate Synthase (dps) Gene in Fission Yeast Suggests a Role of Ubiquinone as an Antioxidant,”J. Biochem, vol. 121, No. 3, 1997, pp. 456-505.
Ikenaka Yasuhiro
Kawamukai Makoto
Matsuda Hideyuki
Yajima Kazuyoshi
Kaneka Corporation
Kenyon & Kenyon LLP
Prouty Rebecca
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