Process for producing cephem compounds in an aqueous medium

Details Process for producing cephem compounds in an aqueous medium Process for producing cephem compounds in an aqueous medium

1997-09-25

1999-12-07

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540215, 540226, 540227, 540228, 540230, C07D50146, C07D50144, C07D50120, C07D50124

Patent

active

059986115

ABSTRACT:
An industrially excellent, novel process for producing cephem compounds which are useful as medicines, particularly, antibiotics and represented by the following formula (III): ##STR1## wherein R.sup.1 means either group represented by the following formula: ##STR2## R.sup.2 denotes a carboxyl group or a carboxyl anion, and R.sup.3 stands for a lower alkyl group, a halogen atom, a lower alkyl group substituted by an aliphatic acyloxy group having 1-6 carbon atoms, or any one of the groups represented by the following formulae: ##STR3## which comprises reacting in water a 3-cephem-4-carboxylate represented by the following formula (I): ##STR4## or a salt thereof with an acid chloride represented by the formula (II), R.sup.1 COCl.

REFERENCES:
patent: 4316019 (1982-02-01), Takaya
Barett, J. Antibiotics 50, pp. 100-102, 1997.

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