Process for producing cephalosporin antibiotics

Details Process for producing cephalosporin antibiotics Process for producing cephalosporin antibiotics

1996-05-01

1999-02-09

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540228, C07D50106

Patent

active

058696490

ABSTRACT:
A process for preparing certain cephalosporin antibiotics, namely, cefotaxime, cefetemet, and ceftriaxone sodium comprising acylation of 7-amino-3-cephem-4-carboxylic acid derivatives with 2-mercapto-5-methyl-1,3,4-thiadiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-metho xyiminoacetate having the formula: ##STR1##

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patent: 5527906 (1996-06-01), Milac et al.
patent: 5574154 (1996-11-01), Abu-Nasrieh
patent: 5583216 (1996-12-01), Ochiai et al.
patent: 5607927 (1997-03-01), Tsushima et al.
Organic Chemistry, Cram & Hammand, 2nd Ed (1964) McGraw Hill Book Co, N.Y.
Tetrahedron Letters, 31, 6481 (1980), Author Donald G. Walker.

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