Process for producing carbohydrate or glycoconjugate

Details Process for producing carbohydrate or glycoconjugate Process for producing carbohydrate or glycoconjugate

1997-08-19

1999-09-21

Prats, Francisco

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 72, 435 74, 435 84, 435 96, 435 98, 435100, 435101, 536 41, 536 172, 536123, 5361231, C12P 1914, C12P 1926, C08B 3708

Patent

active

059553243

ABSTRACT:
To provide a process for producing a carbohydrate or a glycoconjugate without forming any hydrolytic product of the remodeled sugar chain.
A process for producing a carbohydrate or a glycoconjugate by a remodeling reaction in the presence of a glycosidase which performs the remodeling reaction in an aqueous medium containing a water-soluble ketone and/or dioxane. Examples of the glycosidase include endoglycosidases such as Endo-A. Examples of the ketone include acetone.

REFERENCES:
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patent: 5403726 (1995-04-01), Wong et al.
Toone et al, Tetrahedron 45(17): 5365-5422, 1989.
Petit et al, Tetrahedron Letters, 32(43):6125-6128 (1991).
Joziasse et al., ".alpha.1.fwdarw.3-Galactosytransferase: the use of recombinant enzyme for the synthesis of .alpha.-galactosylated glycoconjugates", Eur. J. Biochem. 191, pp. 75-83 (1990).
Trimble et al., "Transfer of Gylcerol by Endo-.beta.-N-acetylglucosaminidase F to Oligosaccharides during Chitobiose Core Cleavage", The Journal of Biological Chemistry, vol. 261, No. 26, pp. 12000-12005, Sep. 15, 1986.
Bardales et al., "Iransgylcoslation and Transfer Reaction Activites of Endo-.alpha.-N-acetyl-D-galactosaminidase from Diplococcus (Streptococcus) pneumoniae", The Journal of Biological Chemistry, vol. 264, No. 33, pp. 19893-19897, Nov. 25, 1989.
The Japanese Biochemical Society, vol. 65, No. 8, 1993.
Kadowaki et al., "Purification and Characterization of a Novel Fungal Endo-.beta.-N-acetylglucosaminidase Acting on Complex Oligosaccharides of Glycoproteins", Agric. Biol. Chem., 54(1), pp. 97-106, 1990.
Yamamoto et al., "Transglycosylation Activity of Mucor hiemalis Endo-.beta.-N-Acetyl-Glucosamindase Moieties Which Transfers Complex Oligosaccharides to the N-Acetylglucosamine Moieties of Peptides", vol. 203, No. 1 Aug. 30, 1994.
Patent Abstracts of Japan, vol. 17, No. 376, (C-1084) Jul. 15, 1993.

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