Process for producing carbapenem derivative and intermediate...

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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C548S556000

Reexamination Certificate

active

07932381

ABSTRACT:
An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, comprising reacting Compound (III) and Compound (IV) in the presence of the secondary amine, and a benzyl alcoholated crystal of Compound (I). There are further provided a method of deprotecting Compound (I) with a Pd catalyst, and a crystal of Compound (IV).

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International Search Report issued Apr. 25, 2006 in International (PCT) Application No. PCT/JP2006/302482.
Form PCT/IB/338 and International Preliminary Report on Patentability including translation of PCT Written Opinion dated Aug. 30, 2007 issued in International (PCT) Application No. PCT/JP2006/302482.
Yutaka Nishino et al., “Practical Large-Scale Synthesis of Doripenem: A Novel 1 β-Methylcarbapenem Antibiotic”, Organic Process Research and Development, vol. 7, No. 6, pp. 846-850, 2003.

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