Process for producing biologically active plasminogen activator

Details Process for producing biologically active plasminogen activator Process for producing biologically active plasminogen activator

1990-05-09

1991-10-01

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C12N 964

Patent

active

050533347

ABSTRACT:
A method of producing biologically active human tissue plasminogen activator in suspension culture is provided wherein recombinant Chinese hamster ovary cells are cultured and certain components detrimental to recovery and biological activity are removed as a cell-free filtrate by cross-flow filtration. The human tissue plasminogen activator is recovered from the culture medium.

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