Process for producing .beta.-lactamase inhibitor

Details Process for producing .beta.-lactamase inhibitor Process for producing .beta.-lactamase inhibitor

1989-05-12

1990-09-18

Therkorn, Ernest G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514192, 514195, 210767, 210774, C07D49900, A61K 31425

Patent

active

049580205

ABSTRACT:
A process for producing the compound [2S-(2.alpha.,3.beta.,5.alpha.)]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-m ethyl)-4-thia-1-azabicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol is toluene at 80.degree.-100.degree. C. for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0.degree.-10.degree. C.

REFERENCES:
patent: 4496484 (1985-01-01), Micetich
patent: 4529592 (1985-07-01), Micetich
patent: 4562073 (1985-12-01), Micetich
patent: 4668514 (1987-05-01), Micetich

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