Process for producing benzylphthalazinone derivatives and salts

Details Process for producing benzylphthalazinone derivatives and salts Process for producing benzylphthalazinone derivatives and salts

1991-11-29

1993-06-01

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

544235, 544237, C07D40314, C07D40304

Patent

active

052161510

ABSTRACT:
A process for producing benzylphthalazinone derivatives represented by the general formula (I); ##STR1## wherein X is a halogen atom and R.sup.1 is a lower alkyl group, and salts thereof, which comprises reacting a compound represented by the general formula (II); ##STR2## wherein X has the same meaning as mentioned above, or a salt thereof with a compound represented by the general formula (III); ##STR3## wherein R.sup.1 has the same meaning as mentioned above or salt thereof in the presence of a dehydration-condensation agent. The benzylphthalazinone derivatives thereof are suitable for use as an antihistaminic agent.

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patent: 4868175 (1989-09-01), Engel et al.
patent: 4939140 (1990-07-01), Larson et al.
Wada et al;, Tetrahedron Lett. No. 13, pp. 1279-1282, (1972).
Grynkiewicz, CA86-140400f (1977).
Ozaki et al. CA 85-108941b (1976).

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