Process for producing benzofuran derivative

Details Process for producing benzofuran derivative Process for producing benzofuran derivative

2008-01-29

2008-01-29

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S330000, C549S331000, C549S342000, C549S343000, C549S344000, C549S345000

Reexamination Certificate

active

07323577

ABSTRACT:
A novel process for efficiently and easily producing a compound represented by the formula:wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula:wherein R1and R2are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula:in-line-formulae description="In-line Formulae" end="lead"?WHin-line-formulae description="In-line Formulae" end="tail"?wherein W iswherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4is a hydrogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof and thereafter, if necessary, deprotecting the resultant product, which is suitable for industrial production.

REFERENCES:
patent: 0 483 772 (1992-05-01), None
patent: WO 00/02887 (2000-01-01), None
patent: WO 00/34262 (2000-06-01), None
patent: WO 01/12618 (2001-02-01), None
patent: WO 02/28850 (2002-04-01), None
Kosugi, M., et al., “Palladium-Catalyzed Aromatic Amination of Aryl Bromides with N,N-Di-Ethylamino-Tributyltin”,Chemistry letters, (1983), pp. 927-928.

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