Process for producing atorvastatin hemicalcium

Details Process for producing atorvastatin hemicalcium Process for producing atorvastatin hemicalcium

2005-08-05

2009-11-10

Chu, Young (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S423000, C548S537000, C548S561000, C548S562000, C548S563000

Reexamination Certificate

active

07615647

ABSTRACT:
A process is provided for preparing pharmaceutical grade atorvastatin hemicalcium salt comprising:(a) deesterifying,wherein R is an ester protecting group to(b) extracting R(R*,R*)-3 into an organic solvent or mixture of solvents,(c) adding a base of formula NR1R2R3wherein R1, R2and R3are independently selected from H, substituted or non-substituted C1 to C7 alkyl, C6 to C9 aryl, C8 to C10 aralkyl or aminoalkyl to form atorvastatin base salt,(d) isolating by precipitation of the above atorvastatin base salt and purifying when necessary,(e) converting atorvastatin base salt to atorvastatin hemicalcium salt by treatment with a calcium salt solution, and(f) isolating the atorvastatin hemicalcium salt.

REFERENCES:
patent: 4681893 (1987-07-01), Roth
patent: 5003080 (1991-03-01), Butler et al.
patent: 5273995 (1993-12-01), Roth
patent: 5298627 (1994-03-01), Butler et al.
patent: 6528661 (2003-03-01), Niddam et al.
patent: 6583295 (2003-06-01), Pflaum
patent: 6841554 (2005-01-01), Taylor et al.
patent: 2004/0220255 (2004-11-01), van der Schaaf et al.
patent: WO-01/36384 (2001-05-01), None
patent: WO-03/068739 (2003-08-01), None
John Landgrebe, Extraction and Drying, Chapter 6, Organic Laboratory, 4thedition, p. 123-132.
Baumann. Kelvin L et al.; The Convergent Synthesis of CI-981. an Optically Active, Highly Potent Tissue Selective Inhibitor of HMG-CoA Reductase; Tetrahedron Letters; vol. 33. No. 17, pp. 2283-2284, 1992; Pergamon Press Ltd., Great Britain.

Affiliated with

Also associated with

Rating

Process for producing atorvastatin hemicalcium does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing atorvastatin hemicalcium, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing atorvastatin hemicalcium will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4071260