Process for producing anticancer agent LL-D45042

Details Process for producing anticancer agent LL-D45042 Process for producing anticancer agent LL-D45042

2006-03-28

2006-03-28

Saucier, Sandra E. (Department: 1651)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C435S041000, C435S053000, C424S093430

Reexamination Certificate

active

07019014

ABSTRACT:
The disclosure describes the production of anticancer agent LL-D45042, having the structure:by fermentation, to methods for the recovery and concentration of this anticancer agent from crude solutions, and to processes for the purification of this anticancer agent as well as a new microorganism of the speciesStreptomyces hygroscopicusLL-D45042 and mutants thereof useful in the preparation of this compound.

REFERENCES:
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patent: WO 94/10843 (1994-05-01), None
patent: WO 94/18208 (1994-08-01), None
patent: WO 95/14023 (1995-05-01), None
Randall Ellis Morris; Transplantation Reviews; vol. 6; pp. 39-87; 1992.
Tom S. Chen, et al.; The Journal of Antibiotics, vol. 45; pp. 118-123; 1992.
Hiroyuki Nishida, et al.; The Journal of Antibiotics; vol. 48; pp. 657-666; 1995.
Lake EE Khaw, et al.; Journal of Bacteriology; vol. 180; pp. 809-814; 1998.

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