Process for producing antibodies to hepatitis virus and cell lin

Details Process for producing antibodies to hepatitis virus and cell lin Process for producing antibodies to hepatitis virus and cell lin

1979-10-22

1981-06-02

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 86, 424 88, 424 89, 435240, 435948, A61K 3900, A61K 3942, C12N 126

Patent

active

042711452

ABSTRACT:
Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibodies to individual antigenic determinates unique to hepatitis virus.

REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
The Lancet, editorial, pp. 1242-1243, Jun. 11, 1977.
Koprowski et al., Proc. Natl. Acad. Sci., USA, vol. 74, pp. 2985-2988, 1977.
Kohler and Milstein, Eur. J. Immunol., vol. 6, pp. 511-519, 1976.
Milstein & Kohler, "Antibodies In Human Diagnosis and Therapy", edited by Haber & Krause, (Raven), pp. 271-278, 1977.

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