Process for producing antibiotic nanaomycin E

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435125, 435886, C12P 1718, C12P 1706, C12R 1465

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active

043539866

ABSTRACT:
The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting material for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.

REFERENCES:
patent: 4194064 (1980-03-01), Omura et al.
patent: 4196266 (1980-04-01), Omura et al.
patent: 4296040 (1981-10-01), Omura et al.

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