Process for producing an antihemophilic factor preparation from

Details Process for producing an antihemophilic factor preparation from Process for producing an antihemophilic factor preparation from

1979-10-26

1981-02-17

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, C07G 700

Patent

active

042514371

ABSTRACT:
An antihemophilic factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 10.sup.8 -10.sup.15 for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10.degree. C. at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer and isolating a concentrated solution which, if desired, is freeze-dried. Irradiation is preferably effected by microwaves of a frequency of 10.sup.8 -3.times.10.sup.11 Hz, in particular 2.times.10.sup.9 -3.times.10.sup.10 Hz, or by infrared light, said frozen plasma being preheated if desired.
The preparation is suitable for injection performed by the patient himself without medical assistance.

REFERENCES:
patent: 2867567 (1959-01-01), Bidwell
patent: 3492212 (1970-01-01), Searcy
patent: 3652530 (1972-03-01), Johnson et al.
Nature, 203, 1964, p. 312, Pool et al.
Transfusion, Nov.-Dec. 1974, vol. 14, No. 6, pp. 595-597, Sherman et al.
J. Lab. Clin. Med. 67, pp. 23-32, Jan. 1966, Hershgold et al.

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