Process for producing an anti-thrombogenic material by graft pol

Details Process for producing an anti-thrombogenic material by graft pol Process for producing an anti-thrombogenic material by graft pol

1987-12-03

1990-01-30

Lieberman, Allan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Compositions to be polymerized by wave energy wherein said...

427 2, 427 35, 427 36, 427 44, 428 357, C08J 328, C08J 716, C08J 718, C08L 5106

Patent

active

048974331

ABSTRACT:
A process for producing a medical material having high anti-thrombogenicity that is suitable for use in catheters and other medical devices in contact with blood flowing in circulatory organs and other tissues is disclosed. According to this process, an acrylamide or methacrylamide derivative having a tertiary amino group, or an unsaturated monomer having a hydrophihlic group and the ability to promote copolymerization, or a mixture thereof is graft polymerized onto a polyurethane elastomeric or polyolefinic high-molecular weight substrate with an ionizing radiation.

REFERENCES:
patent: 4196065 (1980-04-01), Gaussens et al.
patent: 4377010 (1983-03-01), Fydelor et al.
patent: 4717741 (1988-01-01), Hainfeld et al.
Covalent Binding of Biomolecules to Radiation-Grafted Hydrogels or Inert Polymer Surfaces, Trans. Amer. Soc. Artif. Int. Organs 1972, Hoffman et al.; pp. 10-17.
Antithrombogenic Material with Diffuse Layer, Ikada, Y. Jpn. J. Artif. Organs 15(1) 12-15 (1986).
Blood-Compatibility-Water-Content Relationships for Radiation-Grafted Hydrogels, B. D. Radner et al., Journal of Polymer Science Polymer Symposium 66, 363-375 (1979).
Article by A. Nakao et al., Jpn. J. Artif. Organs, 13(3), 1151-1154 (1984).

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