Process for producing an alpha or beta-hydroxy acid-vinylpyrroli

Details Process for producing an alpha or beta-hydroxy acid-vinylpyrroli Process for producing an alpha or beta-hydroxy acid-vinylpyrroli

1995-10-02

1997-07-08

Kolkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 7824, 5147725, A61K 914

Patent

active

056458592

ABSTRACT:
A process is provided for making a free-flowing powder of a complex of an alpha-hydroxy acid (AHA) and/or a beta-hydroxy acid (BHA) and a vinylpyrrolidone (PVP) polymer, copolymer or graft polymers, as the complexing agent, at high acid loadings, preferably 20-60% by weight. The presence of VP polymers, copolymers or graft polymers in the complex reduces the skin irritation effect of the acid when applied to the skin of the user. The process involves applying an aqueous solution or slurry of the acid to PVP, and, substantially immediately thereafter, evaporating the water to form a free-flowing powder of the complex of the acid and VP polymers, copolymers or graft polymers.

REFERENCES:
patent: 4889844 (1989-12-01), Silvetti, Sr. et al.
patent: 4950653 (1990-08-01), Jauw
patent: 5008106 (1991-04-01), Merianos et al.

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