Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1991-08-02
1993-06-08
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435106, 4352523, 43525231, 435822, 4351721, C12R 101, C12R 1304, C12R 1308
Patent
active
052178838
ABSTRACT:
Disclosed is a process for producing amino acids such as L-threohine and L-lysine, which comprises culturing, in a medium containing methanol as a major carbon source, a microorganism which belongs to the genus Methylobacillus and which has an ability to produce the amino acid(s) and resistance to at least one member selected from the group consisting of L-threonine, L-lysine and an amino acid analogue, said microorganism being obtained by mutation of a parent strain which belongs to the genus Methylobacillus and which has an enhanced sensitivity to at least one of an antibiotic and an amino acid analogue; allowing the amino acid(s) to accumulate in the culture; and recovering the amino acid(s) therefrom.
REFERENCES:
patent: 3907637 (1975-09-01), Nakayama et al.
patent: 3907641 (1975-09-01), Nakayama et al.
Japanese Patent Abstract No. 70-25273 "Production of Amino Acids by Fermentation".
APS JP0ABS Araki et al. Japan 01-235595 (Sep. 20, 1989).
Anazawa Hideharu
Motoyama Hiroaki
Teshiba Sadao
Kyowa Hakko Kogyo Co. Ltd.
Lilling Herbert J.
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